مطالعه اثرات برگ درخت گردو بر سطح تعدادی از عوامل بیوشیمیایی خون در موش‌های صحرایی نر دیابتی

Background and Objectives: Diabetes mellitus is characterized as one of the most common endocrine diseases throughout the world. The use of antioxidants is the most preferred way to decrease complications of diabetes mellitus. Several studies showed the antioxidant effects of walnut leaf. Therefore, the aim of the present work was to survey the effects of walnut leaf animal diet on some blood biochemical metabolites in diabetic rats. &nbsp;Materials and Methods: In this experimental study, 40 albino male rats (250-300 gram body weight) were divided into five groups of 8. Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ) (50 mg/kg). Three groups of Diabetic rats received 1%, 2% and 5% weight concentration of walnut leaf powder in daily diets. The study was performed during 28 days. The blood samples were collected at the beginning and the end of study, and biochemical parameters including HbA1c, FBS, TG, HDL-C, LDL-C, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assayed. Statistically, the quantitative data obtained, compared among the groups by ANOVA. Statistical significance was considered at p<0.05. &nbsp;Results: The results of the current study showed that consumption of walnut leaf decreased TG, ALT, ALP, and HbA1c levels significantly. The consumption of 5% walnut leaf had the most effects. But it had no significant effect on FBS. Conclusion: According to the results of the present study, it can be concluded that walnut leaf has useful effects on HbA1c and ALP levels and 5% of walnut leaf powder showed the most effect. Key words: Diabetes Mellitus, Walnut Leaf, Antioxidant, Hyperglycemia, HbA1c, Rat Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study. Funding: This research was funded by Rafsanjan University of Medical Sciences. Conflict of interest: None declared. How to cite this article: Mahmoodi M, Fahmidehkar MA,. Rezaeian, M.R. Hajizadeh, A. Khoshdel, A. Pourrashidi Boshrabadi. Study of the Effects of Walnut Leaf on the Levels of a Number of Blood Biochemical Factors in Diabetic Male Rats. J Rafsanjan Univ Med Sci 2016; 15(8): 753-64. [Farsi]